Thrive Genetics (Unchained Health)

Genetic / Behavioral Addiction Identification Platform

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We identify the genetic & behavioral predisposition of addiction in humanity, leveraging our ai-assisted platform that unlocks limitless possibilities for human well-being.

Company Overview
Thrive Genetics (formally Unchained Health, Inc.) The driving force behind building Thrive Genetics started right “at home” from personal experience and family related trauma. Co-Founder James Piacentino came from a family with an alcoholic father and always had the burning question related to this painful family experience; “Is addiction truly in our genes?” And if so, “can addiction be passed down generation to generation?” Closing the loop on this lifelong uncertainty, Unchained Health has a driving passion for helping others understand their risks. When the Co-Founders met leading Genetics and Psychology Ph. D, Dr. Danielle Dick, with her 20+ years of research on risk prediction for addiction, the idea for the company came to fruition. The team is now focused on first to market commercialization of genetic predisposition management product /solution proving that addiction is both genetic and behavioral. Unchained Health Inc. is now on deferral backed by law firm Perkins Coie. The company is working closely in the clinical field w/ support and leadership from globally recognized celebrity clinician Leah Randi, (Executive Advisor).

The company is currently run by the founders in a pre-market capacity and is set up as an incorporation. Mr. Piacentino and Dr. Dick are equal co-founders with an equity stake also owned by Leah Randi, Executive Advisor. Although the company is early stage, the work that has gone into this entity has been over 20 years of service in scientific and genetic research (DD), 20 years in the software, e-commerce technology sector, venture capital (JP) that will uniquely position this product and service line for mass appeal and success.

The Offering: With over $50+M in US based Grants supporting our science...
The PRODUCT / SaaS Service will consist of two distinctive features (Part 1 & Part 2, see figure) that will allow us to deliver value to customers quantitatively and qualitatively. We will deliver this value through a genetic testing kit that identifies genetic risk for addiction and combines that information with an environmental/behavioral behavior assessment to give personalized risk estimates (Part 1 Quantitative Gene + Environment Assessment).  This will be a SaaS model for B2B with a fee for use including product usage costs.

We will DIFFERENTIATE our offering from the entire market by then offering a service that provides curated and recommended products and services (affiliated marketing programs and interactive journey) to take a proactive approach to your health (Part 2 Qualitative “Life Plan” below). We will help the clinician and YOU manage your data results and maximize your ability. Repeat purchasing will come in the form of Part 2, noted below in the ongoing products the customer will buy via the affiliated marketing programs we will have. The B2B2C Addiction Clinic model will drive volume; the app (Part 2) will be designed to drive long-term customer value, and human development.

Market, Customer, and Competition Focus Areas - The market has several areas of opportunity.

  • B2B: Hospital Systems + Outpatient Medical Hubs15-20M Patients  / 1,920 US based hospitals as Target Market related to mental health and AUD issues
    • Healthcare Providers and Hospitals: Offering AI-assisted genetic and behavioral predisposition analysis can help healthcare providers personalize treatment plans, improve patient outcomes, and reduce the overall cost of care for patients with addiction issue
  • B2C: Athletes and Young Professionals: 30M People as Target Market:
    • The target market will be US citizens aged 18-25 – Through our research, we have done studies that have shown ~80% of emerging adults want their genetic risk scores for substance use outcomes, equating to a possible market size of 24 million individuals in the US. Young professionals who want to shed their party days and previous collegial habits as they build young families and high-profile careers. Millennial and Gen-Z Biohackers. This will be a reachable audience through Social Media channels and Influencers for fitness, wellness, body, and mind. We estimate this market to be 30 million students and young professionals conservatively.

 
Primary / Secondary Economic Buyer: Young professionals + Parents, student athletes who want to start a conversation about risk with their teenagers, responsible use of substances, and the need to attend to their mental health. We will also use social media to spread information about our product to groups and influencers in the substance use space (e.g., the Sober Curious movement).

Competitive Landscape: First mover advantage in this specific addiction space:
The exponential growth in DTC genetic testing means there is a proliferation of DTC genetic companies. Listed below are

illustrative examples, with pricing information and an overview of services offered:

  • thednacompany.com (price point $499) – 38 comprehensive health reports
  • geneticsdigest.com (price point health + ancestry $219) -- ancestry report, 80+. Health reports, 14 allergy reports, 11 metabolism reports
  • geneticlifehacks.com (price point: annual membership $45-$119/year) - provides articles about how to
  • interpret/use genetic results from other companies
    Our product will differ from these companies in three primary ways:
  1. Most genetic testing companies are trying to be “everything to everyone” - We are positioning our product in a very different way, namely, we are targeted individuals interested in the outcome: addiction. Accordingly, our marketing and target audience will be quite different.

  2. These companies focus on providing genetic feedback only. For complex outcomes like addiction, genes are only part of the story; the environment also plays a critical role. Accordingly, genetic information must be combined with behavioral and environmental information to get an accurate risk estimation. This is what our product will do.

  3. Our product is unique in that it will provide risk information and a direct connection to evidence-based programming (and eventually products) that support behavior change.

Milestone Achievements in 9 months:
  • Deferral w/ Perkins Coie in NYC investment of $35K believing in the power of our science and commercial capability model (Q3 2023)
  • Fortune 100 CEO Advisors that were former CEO's (Medical and Retail) (Q3 2023)
  • Pilot first customer w/ leading Northeast Hospital System to test first commercial product launch (Q1 2024)
  • Celebrity commitment to support B2C portion of investment and PSA (top actors and musicians - details can be provided)
  • Continuous weekly pitch meetings with investors at all levels (100+ since Q3 2023).
Next Steps:
One of the advantages of our product are relatively low startup costs associated with the initial build-out and launch of the product. Part 1 (noted above) will involve the initial development of the interactive platform that will provide personalized risk estimates and evidence-based resources targeting the DTC and B2B Markets. Accordingly, the primary costs are associated with website development and personnel to develop further the content to be delivered. In addition, we must set up contracts with DNAGenotek to provide DNA collection kits, order fulfillment, purchase inventory, and Gencove to provide genotyping services. We have established arrangements in place. We must also establish systems for tracking orders and securely storing data on the cloud which is also arranged. The Artificial Intelligence platform would be executed in Part 2 funding for the development platform that will provide a proactive life plan for each customer.

Pre Seed and Seed Funding: We are seeking funding from various channels for the Phase 1 website buildout and product procurement (minimum order of DNA kits/genotyping costs). We are seeking Seed Investment of $500K to lock in the MVP for Q1. Funding, localized state grants angel funding from friends and family who are part of the addiction recovery movement and accredited investors that invest in early-stage and seed-stage companies seeking $5.5M to secure runway, invest in the markets and pivot if needed based on early data. Further, we will seek institutional and corporate venture capital investors downstream and build upon the platform concept leveraging AI to create interest amongst investors as the data of our platform increases in volume and value. In closing, our goal is to work with a long tern strategic investment team that shares our values and has skin in the game.

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