Stemogen –First in Class Patented Stem Cell Regeneration Peptide Supplement.
Website: https://manuspharma.
PEPTIDE INTRODUCTION.
Peptides are universal regulators of numerous processes occurring in living organisms. Peptides are fragments of proteins formed during their partial hydrolysis. In case of violation of the peptidergic regulatory function in the work of cells, a failure occurs, entailing a disorder in the vital activity and functioning of the damaged organ and the whole organism. Peptides also regulate emotional reactions, sleep, sexual behavior, and aggression and exhibit analgesics and many other activities. Peptides are also responsible for the stimulation or suppression of immunity and hematopoiesis. One of the modern lines in stem cell research is the discovery of "messengers," which send "instructions" to those resting in the bone marrow stem cell's precursors to enter the bloodstream and start proliferation and differentiation. The most probable "messengers" can be small polypeptide or protein factors affecting the surface of the resting stem cell and sending a signal to the "movement and action." A limited number of isolated proteins, known as "colony-stimulating factors” (CSF)," promotes the release of stem cells in the bloodstream and differentiation into a mature hematopoietic population.
Therefore, the potential market for peptide drugs began to develop more intensively when, realizing its prospects, drug developers from the global pharmaceutical sector drew attention to it. We have developed the first generation of the approved peptide pharmaceuticals Stemokin – stimulant of stem cells. Its creation suggests the emergence of a new perspective - "endogenous" ways of applying stem cell therapy. As a step forward, the novel compound Stemogen® has been prepared. Stemogen representing a new generation of peptidomimetics, stimulated the proliferation of intact stem cells at systemic and oral application. The 21st century brought advances in developing a significant number of new peptide-based drugs obtaining FDA approvals and coming to the market.
STEMOGEN
One of the most exciting areas of medical research involves the therapeutic action, production, and adaptability of stem cells. Recent empirical developments have prompted considerable interest in the United States and Canada. This interest has resulted in a re-examination of the efficacy of stem cell therapeutics.
Stem cells are precursor cells. They, essentially, serve as universal “cellular templates” to help replicate a variety of damaged cells. When administered, they assume the specific characteristics of the cells damaged by disease, trauma, or, even, aging. They are naturally produced in the bone marrow as part of the immune system. Hematopoietic cells (HSC’s) are the specific stem cells receiving the greatest attention from researchers. They are responsible for the formation of red and white blood cells. A depletion of stem cells can severely impair the effective regeneration and malfunctioning of various organs and systems.
From the research, there are several options for stem cell therapy. Allogeneic therapy uses the stem cells from a matching donor.
Alternatives were deemed necessary to address the drawbacks inherent with conventional stem cell therapies. Since the 1990’s, some European researchers were investigating the possibility of stimulating an individuals’ own immune system to producing an increased number of their own stem cells. Much of the initial research centered around the thymus gland and thymic peptides. The discovery of messenger substances, (ultimately small peptides) has opened an exciting new frontier in stem cell therapy. Peptides serve to regulate many biochemical reactions. Research into the development of novel peptides is one of the “hot topics” in the international biomedical arena. Peptide research has inspired the creation of new derivatives for the regulation of many metabolic process. The research prompted the investigation of endogenous ways of conducting stem cell therapy. The peptides signal the bone-marrow stem cells precursors to enter the bloodstream. Once stimulated and mobilized, they begin proliferation and differentiation. The small messenger polypeptide stimulates the surface of the stem cell sending a signal to enter the bloodstream.
The most intriguing aspect of the research has involved novel modes of administration. Injection and transfusion are the standards in current therapy. While intranasal administration has been successfully conducted, this has dosage-associated drawbacks.
The most recent discovery involves the conversion of a small peptides in to cyclic peptidomimetics, to allow survival through the digestive tract. Before this discovery, the small peptides proved to be too fragile to survive the gastro-intestinal environment. Because of this development, a proprietary product known as STEMOGEN can be administered orally. Taken orally, STEMOGEN naturally stimulates the differentiation of the naïve internal human stem cells. It is an attractive alternative to exogenous therapy. In doing so, it eliminates the problems associated with injecting and/or transfusing external stem cells of any origin.
STEMOGEN comes from thinking “out-of-the-box”. It represents a very different approach. It is the result of multiple generations of endogenous peptide-based stem cell therapy. (See Manus website).
An active ingredient of STEMOGEN is tripeptide alanyl-glutamyl-gamma-tryptophan. It has the ability to activate the propagation of hemopoietic stem cells and mobilize them to the bloodstream. Combining the tripeptide with Zinc the positive properties are significantly enhanced.
As a dietary supplement, STEMOGEN has been shown clinically to improve the quality of life of different age groups. It is intended to mobilize their own forces for maintaining a higher level of physical and mental activity and healthy longevity. STEMOGEN helps promote antioxidant and detoxifying activity, and immune-modulatory processes. The stem cell therapeutic process helps enhance physical activity, increase stamina, mediate the impact of stress, normalize sleep and memory, and mobilizes the ability to resist numerous adverse environmental factors.
Ready to Ask For Funding for your company?
Post a Funding Request